Elaine Hunter is a Daphne Jackson Research Fellow at the University of Glasgow. Her research career began investigating the interplay between membrane potential, calcium stores and contractility in vascular smooth muscle. Elaine is returning to research after a career break. She is interested in the pathophysiology of Rett Syndrome and in particular, the relationship between neuronal excitability and mitochondrial function.

 

Elaine Hunter (nee Flynn) began her training in Biomedical Science, before commencing graduate studies at the University of Nevada School of Medicine, Reno, USA.  Her Ph. D. research programme with Professor Kenton Sanders investigated Ionic Conductances Involved In The Electrical Activity Of The Canine Gastrointestinal Tract”. Elaine has worked with Dr. J. McCarron investigating Ca2+ handling in smooth muscle, and Professor Alison Gurney on the regulation of hypoxia in then pulmonary vasculature.

 

 

Selected publications:

  1. Gurney, A.M. and Hunter, E. (2005) The use of small interfering RNA to elucidate the activity and function of ion channel genes in an intact tissue. J Pharmacol Toxicol Methods.
  2. 51(3), 253-62.
  3. Bradley, K.N., Flynn, E.R.M., Muir, T.C. and McCarron, J.G. (2002) Ca2+ regulation in guinea- pig colonic smooth muscle: the role of the Na+-Ca2+ exchanger and the sarcoplasmic reticulum. J Physiol. 538(Pt 2), 465-82.
  4. Flynn, E.R.M., Bradley, K.N., Muir, T.C. and McCarron, J.G. (2001) Functionally separate intracellular Ca2+ stores in smooth muscle. J Biol Chem. 276(39),36411-8.
  5. McCarron, J.G., Flynn, E.R.M., Bradley, K.N. and Muir, T.C. (2000) Two Ca2+ entry pathways mediate InsP3-sensitive store refilling in guinea-pig colonic smooth muscle. J Physiol. 525 Pt 1, 113-24.
  6. Bradley, K.K., Hatton, W.J., Mason, H.S., Walker, R.L., Flynn, E.R.M., Kenyon, J.L. And Horowitz, B. (2000) Kir3.1/3.2 encodes an I(K ACh)-like current in gastrointestinal myocytes. Am J Physiol Gastrointest Liver Physiol. 278(2), G289-96.
  7. Flynn, E.R.M., McManus, C.A., Bradley, K.K., Koh, S.D., Hegarty, T.M., Horowitz, B. and Sanders, K.M. (1999) Inward rectifier potassium conductance regulates membrane potential of canine colonic smooth muscle. J Physiol. 518 ( Pt 1), 247-56.
  8. Bradley, K.K., Jaggar, J.H., Bonev, A.D., Heppner, T.J., Flynn, E.R.M., Nelson, M.T. and Horowitz, B. (1999) Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells. J Physiol. 515 ( Pt 3), 639-51.
  9. Schmalz, F., Kinsella, J., Koh, S.D., Vogalis, F., Schneider, A., Flynn, E.R.M., Kenyon, J.L. and Horowitz, B. (1998) Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am J Physiol. Gastrointest Liver Physiol. 274(5 Pt 1), G901-11.